Chrome 51 disabled support for NPN, or Next Protocol Negotiation, the mechanism that millions of nginx servers needed to establish HTTP/2 connections with Chrome users. For anyone running nginx compiled against OpenSSL 1.0.1, Chrome 51 users are still connecting over SSL, but only via the legacy HTTP/1.1 specification, which lacks the performance benefits HTTP/2 imparts.
Both the nginx project, and Mattias Geniar, provide lengthier explanations of what changed in Chrome 51:
For those wondering how to restore HTTP/2 support for Chrome 51 users, there is but one answer: switch nginx to OpenSSL 1.0.2. While OpenSSL 1.0.1 is only receiving security updates (and will stop receiving any updates after December 31, 2016), OpenSSL 1.0.2 is actively maintained and receiving new features, including the successor to NPN, which nginx supports: ALPN, or Application-layer Protocol Negotiation.